A high-quality cell line with stable production qualities is critical in the manufacture of biopharmaceuticals. However, given the number of factors that can influence cell line quality, the increasing complexity of biologics, and the growing regulatory requirements regarding proof of clonality, achieving such a cell line can be cumbersome.
Download this article to learn more about overcoming challenges in cell line selection and optimizing biotherapeutic production from Dr Louis Boon, Chief Scientific Officer at Polpharma Biologics Utrecht.
Techniques covered in this article include:
- A method designed to influence the charge profiles of the biological to improve cell-specific productivity
- A technique developed to precisely modify the critical quality attributes of the biological to optimize effector functions
- An automated, high throughput approach to search and select the optimum high-yielding proven monoclonal cell line